On Sept. 29, 2021, VBI Vaccines announced positive results from multiple preclinical studies against several COVID-19 variants of concern as well as the initiation of dosing in the Phase 1b portion of the ongoing clinical study of VBIﾒs SARS-CoV-2 vaccine candidates in approximately 80 adults age 18-54.

VBI’s coronavirus pipeline, which includes multiple vaccine candidates developed using the Company’s proprietary enveloped virus-like particle (eVLP) technology platform, is being developed with the objective to increase the breadth of protection against known and emerging variants of COVID-19.  The lead vaccine candidates include:

• VBI-2902: eVLP candidate expressing the prefusion ancestral SARS-CoV-2 spike protein – as previously announced in June 2021, demonstrated robust immunogenicity and a clean safety profile in the Phase 1a portion of the clinical study
• VBI-2905: eVLP candidate expressing a modified prefusion spike protein of the SARS-CoV-2 Beta variant of concern – in current, ongoing Phase 1b clinical study
• VBI-2901: Trivalent eVLP candidate, expressing the prefusion spike protein of ancestral SARS-CoV-2, in addition to the spike proteins from SARS-CoV, and MERS-CoV – first clinical study is expected to initiate H1 2022

Data will be submitted for peer-review to a scientific journal. The manuscript is currently available on the online pre-print server, bioRxiv