On May 27, 2020, Heat Biologics announced a collaboration with Waisman Biomanufacturing to establish a partnership for the manufacture of Heat’s COVID-19 vaccine. Waisman specializes in the manufacture of cellular therapeutics and other biologics for early-stage clinical trials and is part of the University of Wisconsin, Madison. To date, it has manufactured over 320 clinical grade products, earning a reputation for cost-effective and timely production of quality biologics.

Heat Biologics previously worked with Waisman to manufacture Heat’s HS-130, which is currently in a Phase 1 clinical trial, and is collaborating with Waisman to support the manufacturing of its COVID-19 vaccine for expected Phase 1 trials in humans. The vaccine leverages Heat’s proprietary gp96 platform to target the SARS-CoV-2 coronavirus that causes COVID-19. Heat’s unique approach is designed to induce a multi-epitope specific memory CD8 T-cell response that protects against multiple, distinct coronavirus strains and against potential future mutations of SARS-CoV-2 and other coronaviruses.

Heat Biologics is a biopharmaceutical company developing immunotherapies designed to activate a patient’s immune system against cancer and other diseases using its proprietary gp96 platform to activate CD8+ “Killer” T-cells. Heat has completed enrollment in its Phase 2 clinical trial for advanced non-small cell lung cancer with its gp96-based HS-110 therapeutic vaccine. HS-110 is the company’s first biologic product candidate in a series of proprietary immunotherapies designed to stimulate a patient’s own T-cells. Heat Biologics has also launched a program in collaboration with the University of Miami to develop a vaccine designed to protect against the COVID-19 Coronavirus. Heat has numerous other pre-clinical programs at various stages of development.