On May 6, 2026, Eli Lilly announced an additional $4.5 billion investment across two of its three Lebanon sites in Indiana—bringing the company’s total Indiana capital expansion commitments since 2020 to more than $21 billion. Lilly’s evolving pipeline, as well as anticipated demand for its medicines, prompted this additional commitment. The investment will incorporate new process designs and technologies at Lilly Lebanon API, one of the company’s future active pharmaceutical ingredient sites, as well as Lilly Lebanon Advanced Therapies, its first dedicated genetic medicine manufacturing facility opening today.

Lilly Lebanon Advanced Therapies is designed to support both clinical and commercial production of advanced therapies that target disease at the genetic level and will include a full spectrum of genetic medicine modalities from research-stage development through large-scale commercial supply. Designing and building for these modalities required developing new manufacturing processes without established commercial precedent. This facility is the first of three planned sites on the Lebanon campus, which will also include Lilly Lebanon API and the Lilly Medicine Foundry.

Lebanon is the cornerstone of Lilly’s domestic manufacturing buildout. In 2024, Lilly announced plans to make both Zepbound® (tirzepatide) and Mounjaro® (tirzepatide), the most prescribed injectable medications for weight management and type 2 diabetes respectively, at its Lebanon API site. Today’s investment expands that commitment further, including planned production of Foundayo™ (orforglipron), Lilly’s first FDA-approved, once-daily pill for weight loss that can be taken without food or water restrictions, and retatrutide, an investigational triple hormone receptor agonist in late-stage development for obesity and cardiometabolic disease.