On May 19, 2021, APEIRON Biologics announced the next development steps for APN01 (alunacedase alfa) for the treatment of COVID-19. Based on the recently announced clinical results from APEIRON’s Phase 2 trial with APN01 in COVID-19, APN01 will be developed in further international clinical trials with different COVID-19 patient populations and drug delivery routes.

APN01, a drug candidate of APEIRON, is based on previous work in the early 2000s, when Penninger, together with Drs. Arthur Slutsky (University of Toronto) and Chengyu Jiang (Peking Medical Union College), discovered that a protein called ACE2 was the critical receptor for the SARS virus and also protected the lung.

During the trial, which will begin shortly in China, researchers will assess participants to determine if APN01 reduces the viral load of SARS-CoV-2 virus, as well as the number of days patients endure fever. Data from the trial will be evaluated to determine if there is a need for an additional clinical trial in a larger number of patients.

An international team of Canadian, Chinese, and European experts, including Penninger, co-founder of APEIRON and the APEIRON team, Dr. Liqun Zhang and team of Angalpharma Co., Ltd (Suzhou, China), are coordinating the Chinese clinical trial with the support of dMed Pharmaceutical Co., a CRO team based in China. Drs. Haibo Zhang and Arthur Slutsky at St. Michaels Hospital in Toronto will determine if APN01 improves severe disease of the new coronavirus outbreak.

The trial in China is being led by Dr. Yimin Li, the ICU director who fought the 2003 SARS outbreak Guangdong Province, and Dr. Nanshan Zhong, the Chair of the National COVID-19 Commission in China.