On Aug. 9,  2011, the Siteman Cancer Center announced that it had performed its 5,000th bone marrow transplant, a landmark moment as one of the top cancer centers in the U.S. The 5000th transplant patient is Gary Ronchetto, 60, of Morrisonville, IL, who received his transplant from Ravi Vij, MD, to fight multiple myeloma.

“Taking care of one transplant patient is a phenomenal amount of work,” says John DiPersio, MD, PhD, Siteman deputy director and chief of the Division of Oncology at Washington University School of Medicine. “It requires a critical mass of physicians, physician-scientists, nurses and nurse practitioners. To have achieved 5,000 – it’s an enormous undertaking.”

The 5000th transplant patient is Gary Ronchetto, 60, of Morrisonville, IL, who received his transplant from Ravi Vij, MD, to fight multiple myeloma. “We’re lucky this was an option,” says Mary Ronchetto of her husband’s transplant. “Things like this are just not available at most hospitals.”

The transplant program was established at Washington University in 1980. The first recorded transplant was performed in 1982 with marrow from a matched sibling pair. This year, the program expects to perform 400 transplants, including about 200 allogeneic transplants, making it one of the largest transplant centers in the country.

In recent years, Siteman physicians have conducted clinical studies that led to the approval of plerixafor as a mobilizing agent in patients with non-Hodgkin lymphoma and multiple myeloma, and decitabine as a first-line treatment for elderly patients with acute myelogenous leukemia (AML). They also were the first to use a novel suicide gene for gene therapy to control graft-versus-host disease.

In 2008, scientists affiliated with Siteman and Washington University’s Genome Institute became the first in the world to sequence the genome of a cancer patient, a woman with AML. This achievement has been followed by a series of studies that highlight the diagnostic and therapeutic potential of whole-genome sequencing in hematologic malignancies.