In 1864, Rebecca Lee Crumpler challenged the prejudice that prevented African Americans from pursuing careers in medicine to became the first African American woman in the United States to earn an M.D. degree, a distinction formerly credited to Rebecca Cole.

In 1860, she was admitted to the New England Female Medical College. When she graduated, Crumpler was the first African American woman in the United States to earn an M.D. degree, and the only African American woman to graduate from the New England Female Medical College, which merged with Boston University School of Medicine in 1873.

In her Book of Medical Discourses, published in 1883, she gives a brief summary of her career path: “It may be well to state here that, having been reared by a kind aunt in Pennsylvania, whose usefulness with the sick was continually sought, I early conceived a liking for, and sought every opportunity to relieve the sufferings of others. Later in life I devoted my time, when best I could, to nursing as a business, serving under different doctors for a period of eight years (from 1852 to 1860); most of the time at my adopted home in Charlestown, Middlesex County, Massachusetts. From these doctors I received letters commending me to the faculty of the New England Female Medical College, whence, four years afterward, I received the degree of doctress of medicine.”