On May 1, 2024, the National Institutes of Health’s (NIH) All of Us Research Program announced that it had returned personalized health-related DNA results to more than 100,000 participants. In doing so, the program looked at a specific set of genes that are associated with certain serious health conditions, such as hereditary cancers and heart disease, and observed 32,500 DNA variants. More than 7,000 of these variants had never been observed among people who had previously had genetic testing.

This de-identified information has been added to the public database, ClinVar. Managed by the National Center for Biotechnology Information at NIH’s National Library of Medicine, ClinVar aggregates information about genomic variation and its relationship to human health. Health care providers use this database to help diagnose and manage health conditions, and researchers use it to identify new areas of study.

More than 230,000 participants have already been invited to receive health-related DNA results, and the program continues to invite 1,000 to 5,000 people each week to view their results. By providing this information to participants, All of Us looks to return value to participants in their role as partners of the research program. Those who are still waiting for their results will receive updates on the program’s next steps in the coming months.

All of Us works with a large network of partners around the country to enroll participants, gather their data, and return DNA results. More than 790,000 people have joined All of Us to contribute to this research effort. Participants can share data from biosamples, surveys, physical measurements, electronic health records (EHRs), and wearable devices.

These comprehensive data are made broadly accessible to registered researchers through the program’s Researcher Workbench to help spur biomedical research discoveries and ultimately advance health equity.