On Jun. 30, 2021, Gavi, the Vaccine Alliance, announced that it had signed an advance purchase agreement with Clover Biopharmaceuticals for its SCB-2019 protein-based adjuvanted vaccine candidate against COVID-19. The agreement included up to 414 million doses available to participants of the COVAX Facility.

Under the APA, Gavi commits to purchase, on behalf of the COVAX Facility, 64 million doses to be made available in 2021 and has the option to purchase up to 350 million doses in 2022. Supply of the vaccine is anticipated to commence in Q4 2021, pending WHO EUL. In order to address the rising threat of variants, the agreement also provides the opportunity to access doses of potential variant-adapted vaccine in the future.

The COVAX Facility portfolio, administered by Gavi, currently consists of agreements related to 9 vaccines and vaccine candidates – AstraZeneca/Oxford, Clover, Johnson & Johnson, Moderna, Novavax, Pfizer-BioNTech, SII-Covishield, SII-Covovax, and Sanofi/GSK – with the aim to expand to 10-12 vaccines in total, providing participants access to a diverse range of vaccines suitable for use in varied contexts and settings, and to mitigate against the risk of R&D failures, regulatory delays and supply constraints.