On Feb. 9, 2024, the state of Alaska Department of Health Alaska Department of Health confirmed the first fatal case of Alaskapox virus occurred in late January.

In mid-September 2023, an elderly man from the Kenai Peninsula with a history of drug-induced immunosuppression secondary to cancer treatment noted a tender red papule in the right axilla. He later exhibited delayed wound healing, malnutrition, acute renal failure, and respiratory failure. He died in late January 2024.