On Oct. 12, 2023, the U.S. Centers for Disease Control and Prevention (CDC) announced that two fatal human infections with highly pathogenic avian influenza (HPAI) A H5N1 (bird flu) virus have been reported by Cambodia. These are the third and fourth human infections with HPAI H5N1 bird flu reported by Cambodia this year. These two fatal infections in Cambodia were in a child and an adult, both of whom had exposure to poultry prior to their illness.