On May 30, 2019, a report from the nation’s leading cancer organizations found that Americans’ risk of dying from cancer continued to drop, maintaining a trend that began in the early 1990s. Overall cancer incidence rates (per 100 000) for all ages during 2011-2015 were 494.3 among male patients and 420.5 among female patients; during the same time period, incidence rates decreased 2.1% per year in men and were stable in females. Overall cancer death rates (per 100 000) for all ages during 2012ﾖ2016 were 193.1 among male patients and 137.7 among female patients.

The death rate for (per 100 000) adults age 20–49 years for all cancer sites combined during 2012 to 2016 was 22.8 among men and 27.1 among women; during the same time period, death rates decreased 2.3% (95% CI = −2.4% to −2.2%) per year among men and 1.7% (95% CI = −1.8% to −1.6%) per year among women.

Among people of all ages and ages 20–49 years, favorable as well as unfavorable trends in site-specific cancer incidence were observed, whereas trends in death rates were generally favorable. Characterizing the cancer burden may inform research and cancer-control efforts.