In 2007, the World Health Organization (WHO) reported the first significant outbreaks of Zika virus infection involving more than a few persons were detected in Libreville, Gabon and towns to the north. Five human sera and two A. albopictus pools, all sampled in an urban locations, tested positive.

Other outbreaks of ZIKV infection involving more than a few persons were detected in Yap, an island that is part of the Federated States of Micronesia. Up to 73% of the 7391 Yap residents were estimated to have been infected and A.