In 1999, Dr. Emil Kakkis at Los Angeles Biomedical Research Institute (LA BioMed) developed Enzyme Replacement Therapy to treat Hurler-Scheie Syndrome. The Institute was founded in 1952. Today, LA BioMed is a 501(c)3 independent non-profit biomedical research organization that has more than 120 principal investigators and 400 researchers in total ﾗ MDﾒs, MD/PhDﾒs, and PhDﾒs ﾗ working on over 1,000 research studies. The Institutes are academically affiliated with the David Geffen School of Medicine at UCLA and work in partnership with the Harbor-UCLA Medical Center.