In 1991, a sharp increase of tuberculosis was reported by the U.S. Centers for Disease Control and Prevention (CDC), related to HIV infection and AIDS.

The CDC reported 26,673 cases of tuberculosis (TB) (10.5 cases per 100,000 population) were reported to from the 50 states, the District of Columbia, and New York City, a 1.5% increase over the number reported in 1991 (26,283 {10.4 cases per 100,000}). In addition, 370 cases were reported from Puerto Rico (312) and the U.S. territories