In 1980, the U.S. Centers for Disease Control and Prevention (CDC) reported on the association of Reye Syndrome with aspirin use.

While less than 0.1% of children who took aspirin developed Reye syndrome, more than 80% of children diagnosed with Reye syndrome had taken aspirin in the preceding 3 weeks. This data led to recommendations against the use of aspirin in children in 1980.

The number of reported cases of Reye syndrome fell dramatically following the widespread warnings against the use of aspirin in children.