On Jul. 31, 2024, the Lancet Standing Commission released its 2024 Dementia prevention, intervention, and care report that projects the number of people living with dementia worldwide, estimated at 57 million in 2019, is projected to increase to 153 million by 2050.

The 2024 report of the Lancet Commission on dementia prevention, intervention, and care adds compelling new evidence that untreated vision loss and high LDL cholesterol are risk factors for dementia. Overall, around 45% of cases of dementia are potentially preventable by addressing 14 modifiable risk factors at different stages during the life course.

Evidence for specific risk factors suggested that all children should be educated, and a long duration of education is beneficial. It is important to be cognitively, physically, and socially active in midlife (ie, aged 18–65 years) and late life (ie, aged >65 years), with novel evidence showing that midlife cognitive activity makes a difference even in people who received little education.