On Nov. 9, 2024, the World Health Organization announced that three additional countries had confirmed travel-related cases of clade Ib MPXV: the United Kingdom of Great Britain and Northern Ireland, Zambia and Zimbabwe.

This was the first time that a local transmission of clade Ib MPXV was reported outside of Africa, in the United Kingdom of Great Britain and Northern Ireland. All three household members of the initial case that were confirmed to have mpox, had travelled to affected East African countries where the clade Ib) were confirmed to have mpox.

The epicentre of the outbreak was the Democratic Republic of the Congo, with over 38,000 suspected cases and over 1000 deaths reported to date. The first round of mpox vaccination has concluded in the Democratic Republic of the Congo, with around 51,500 people vaccinated across six provinces: Equateur, South Kivu, Nord Kivu, Sankuru, Sud Ubangi and Tshopo.