In 1839, two medical colleges merged into the the Medical College of the State of South Carolina. In 1832, the faculty and the Medical Society disagreed on management of the school. The faculty resigned as a body and applied to the General Assembly for a charter for the Medical College of the State of South Carolina.

The factions reconciled in 1839, and the faculty moved back into the society building, but the school retained the newer name of the Medical College of the State of South Carolina.