In 1932, the Tumor Institute of the Swedish Hospital opened its doors. Children’s Orthopedic Hospital Association, later known as Children’s Hospital and Regional Medical Center, was incorporated in 1907 by Anna Clise creating the first pediatric facility in the Northwest.

In 1898, tragedy struck the Clise family when their youngest son, 6-year-old Willis succumbed to untreatable inflammatory rheumatism. At that time, the closest children’s hospital was in San Francisco. Out of this tragedy, Anna Clise, with her family and other Seattle community leaders founded the Children’s Hospital Association.