In 1973, the Ohio State University Cancer Center (OSUCCC) was established in Columbus. The patient care arm of the OSUCCC is the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The center is known as the OSUCCC – James.

The National Cancer Institute (NCI) designated Ohio State University as a comprehensive cancer center in 1976. The adult patient care component of the OSUCCC is the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, which opened in 1990 and was replaced in 2014 by a much larger cancer hospital of the same name.

Clinical partners of the OSUCCC – James include The Ohio State University Wexner Medical Center, also on the Ohio State campus, and Nationwide Children’s Hospital in Columbus, Ohio. The OSUCCC – James is funded by the NCI to conduct both phase I and phase II clinical trials on novel anticancer agents provided by the NCI.