On Dec. 16, 2020, National Institute of Allergy and Infectious Diseases reported that an observational study had launched to evaluate the short- and long-term health outcomes of SARS-CoV-2 infection in children, including multisystem inflammatory syndrome in children (MIS-C), and to characterize the immunologic pathways associated with different disease presentations and outcomes.

The study, called the Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM), enrolled at least 250 children and young adults ages 20 years or younger from diverse racial and ethnic backgrounds at approximately 20 sites nationwide.