On Dec. 10, 2014, Dr. Andras Nagy, from the University of Toronto and leader of Project Grandiose, announced an international effort to map the genomic and proteomic pathways during de-differentiation of induced pluripotential stems cells. The Project Grandiose secondary reprogramming samples presented a unique opportunity to profile cellular state changes at various time points during reprogramming.

The detailed analyses of the data generated and reported in the five papers helps to better understand this process which is critical to generating safe and highly-efficient sources for therapeutic cell production.The study results were published in Nature.