On Jun. 1, 2021, CytoDyn announced that Chiral Pharma in the Philippines placed its first purchase order for leronlimab under a Compassionate Special Permit to treat critically ill COVID-19 patients in the Philippines.

The U.S. Food and Drug Administration (FDA) granted CytoDyn Fast Track designation to explore two potential indications using leronlimab to treat Human Immunodeficiency Virus (HIV) and metastatic cancer.