As of Oct. 24, 2025, the South Carolina Department of Public Health (DPH) reported 33 cases of measles and since July 9, 30 cases were centered around Spartanburg County in the current outbreak.

On October 2, 2025, DPH confirmed a measles outbreak in Upstate region. An outbreak is defined as three or more cases of the same infectious disease linked to a common exposure. There has been a rise in measles cases in the Upstate this year, with most concentrated in Spartanburg County. 

Some cases are travel-related exposures or close contacts of known cases. Other cases have no identified source, suggesting that measles is circulating in the community and could spread further. They have seen measles spread quickly in unvaccinated households in South Carolina. They also know that it can spread quickly in unvaccinated communities based on outbreaks in other states. 

Measles is highly contagious and a person is contagious four days before and after a rash begins, meaning someone can spread measles before they know they are infected. The virus can linger in the air for up to two hours after an infected person leaves.

In response to the ongoing measles outbreak, the DPH has activated its Mobile Health Unit to deploy to the following locations to offer measles-mumps-rubella (MMR) vaccine to unvaccinated individuals at no cost.