On Sept. 7, 2020, research from the Children’s Medical Center Research Institute at UT Southwestern (CRI) determined how mutations in two key SWI/SNF proteins, ARID1A and ARID1B, can drive cancer development by disrupting the assembly of SWI/SNF complexes.

The study, published in Nature Cancer, addressed fundamental questions about SWI/SNF biology as well as therapeutic strategies designed to kill cancer cells by targeting this complex.