On Dec. 13, 2023, In a study of historic scale, scientists at Gladstone Institutes announced that they had created an intricate map of how the immune system functions, examining the molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.

Their findings, published in Nature, uncover detailed information that could help overcome the limitations of todayﾒs immunotherapies and identify new drug targets for a wide range of conditions, including autoimmune diseases and cancer.