On Apr. 20, 2022, Tonix Pharmaceuticals announced the results of a retrospective observational database study in over 50,000 patients diagnosed with Long COVID1-2. Long COVID is known officially as Post-Acute Sequelae of COVID-19 (PASC3).

Tonix previously announced that the U.S. Food and Drug Administration had cleared the Investigational New Drug application to support a Phase 2 clinical trial with TNX-102 SL4 (cyclobenzaprine HCl tablets for sublingual administration) as a potential treatment for a subset of patients with Long COVID whose symptoms overlap with fibromyalgia, and expects to initiate this study in the second quarter. The goal of the retrospective database study was to assess the proportion of Long COVID patients who experience fibromyalgia-like multi-site pain and to measure their use of opiates.