On Oct. 12, 1999, the Institute for Systems Biology (ISB) was founded in Seattle by Alan Aderem, Ruedi Aebersold, and Leroy Hood. A non-profit research institute, ISB was established on the belief that conventional models for exploring and funding breakthrough science have not caught up with their potential.

To date, ISB had spun-off eight companies and in 2016, ISB and Providence Health & Services announced an affiliation to bring personalized medicine to patients through collaborative research and clinical care.