The genome of the 1918 H1N1 pandemic influenza virus was sequenced
On Oct. 7, 2005, Jeffery Taubenberger, AH Reid, AE Krafft, Karen Bijwaard and Thomas Fanning published a report in Science that described the isolation of the genes from the deadly 1918 flu virus.
RNA from a victim of the 1918 pandemic was isolated from a formalin-fixed, paraffin-embedded, lung tissue sample. Nine fragments of viral RNA were sequenced from the coding regions of hemagglutinin, neuraminidase, nucleoprotein, matrix protein 1, and matrix protein 2.
The sequences were consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup.
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Source: U.S. National Library of Medicine
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