The first of some 50 now known human proto-oncogenes were discovered (c-src)
In 1976, Drs. J. Michael Bishop and Harold E. Varmus of the University of California, San Francisco demonstrated that oncogenes were defective proto-oncogenes, found in many organisms including humans. Bishop and Varmus were awarded the Nobel Prize in Physiology or Medicine in 1989 for this discovery.
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Source: U.S. National Library of Medicine
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