In 1976, the American Liver Foundation (ALF) was created as a 501(c)3 nonprofit by the American Association for the Study of Liver Disease (AASLD). This organization of scientists and healthcare professionals was concerned with the rising incidence of liver disease and the lack of awareness among both the general public and the medical community.

The ALF mission is to promote education, advocacy, support services and research for the prevention, treatment and cure of liver disease.