Roman emperor Justinian ordered travelers from plague infected regions isolated

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Emperor Justinian I (482-565 BCE) contracted the plague, but survived. A series of laws were enacted against those individuals he believed to be most responsible for the epidemic, including Jews, Samaritans, pagans, heretics, Arians, Montanists, and homosexuals. These laws created an artificial (and very porous) quarantine around Constantinople.

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Source: The Virginia Tech Undergraduate Historical Review
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