On Nov. 28, 2013 “Project Tycho,” was a mammoth study that tracked nearly 88 million cases of disease throughout thousands of America’s biggest cities and extrapolated all the likely additional cases had their not been vaccines, was published in the New England Journal of Medicine.

Project Tycho provided open access to newly digitized and integrated data from the entire 125 years history of United States weekly nationally notifiable disease surveillance data since 1888.