On May 5, 2023, the National Institutes of Health reported that a study had identified features of Long COVID neurological symptoms that offer insight into biological mechanisms, pointing to possible treatments.

Twelve people with persistent neurological symptoms after SARS-CoV-2 infection were intensely studied at the NIH and were found to have differences in their immune cell profiles and autonomic dysfunction. These data inform future studies to help explain persistent neurological symptoms in Long COVID.

The results showed that people with Long COVID had lower levels of CD4+ and CD8+ T cellsﾗimmune cells involved in coordinating the immune systemﾒs response to virusesﾗcompared to healthy controls. The findings, published in Neurology: Neuroimmunology & Neuroinflammation.