On Mar. 6, 2008, DNA mutations found in a type of non-Hodgkin lymphoma that has a poor prognosis has led National Cancer Institute researchers to a better understanding of how the cancer develops and how it might be treated.

To determine how CARD11 contributes to cancer, researchers sequenced the CARD11 gene in human DLBCL tumors and detected mutations in about 10 percent of ABC DLBCL biopsy specimens. The research findings appeared in Science.