In 1938, John Bozicevich developed immunological methods for the diagnosis of helminth parasitic infections. Helminthiasis, also known as worm infection, is any macroparasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as helminths.

There are numerous species of these parasites, which are broadly classified into tapeworms, flukes, and roundworms.