Imaging technique shows new details of peptide structures

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On Apr. 26, 2024, engineers at Washington University in St. Louis announced a new imaging technique that give scientists a much closer look at fibril assemblies — stacks of peptides that include amyloid beta, most notably associated with Alzheimer’s disease. The paper was published in ACS Nano.

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Source: The SOURCE/Science & Technology
Credit: Image: Single-molecule orientation–localization microscopy captures fluorescence from Nile red molecules as they transiently bind to fibrils composed of engineered KFE8 peptides, courtesy Weiyan Zhou.