On Apr. 1, 2020, Cumberland Pharma announced a national initiative to support hospitals and clinics that use Caldolor (ibuprofen) injection for the treatment of patients with fever, severe hyperthermia and other symptoms associated with COVID-19 infections.

Because of the potential dangers of a high fever, new guidelines from the Society of Critical Care Medicine suggested that clinicians consider using pharmacologic agents for controlling fever in COIVD-19 patients.