On Jul. 19, 2013, the U.S. Centers for Disease Control and Prevention (CDC) issued updated recommendations for use of VariZIG immune globulin for varicella postexposure prophylaxis. VariZIG is supplied in 125-IU vials and should be administered intramuscularly as directed by the manufacturer. The recommended dose is 125 IU/10 kg of body weight, up to a maximum of 625 IU (five vials). The minimum dose is 62.5 IU (0.5 vial) for patients weighing =2.0 kg and 125 IU (one vial) for patients weighing 2.1ﾖ10.0 kg (2).