On Nov. 10, 1922, Carl Voegtlin, J. M. Johnson, and Helen Dyer announced they had co-published an article ‘Sulpharsphenamine: Its Manufacture and Its Chemical and Chemotherapeutic Properties‘ in Public Health Reports.

The data presented show that sulpharsphenamine is an arsphenamine derivative very closely related in chemical structure to nieoarsphenamiiie. This slight change in chemical constitution, however, imparts to the drug certain definite advantages over neoarspheinamin.