On May 1, 2024, the National Institutes of Health’s (NIH) All of Us Research Program announced that it had returned personalized health-related DNA results to more than 100,000 participants. In doing so, the program looked at a specific set of genes that are associated with certain serious health conditions, such as hereditary cancers and heart disease, and observed 32,500 DNA variants. More than 7,000 of these variants had never been observed among people who had previously had genetic testing.

This de-identified information has been added to the public database, ClinVar. Managed by the National Center for Biotechnology Information at NIH’s National Library of Medicine, ClinVar aggregates information about genomic variation and its relationship to human health. Health care providers use this database to help diagnose and manage health conditions, and researchers use it to identify new areas of study.