On Dec. 8, 2021, In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease. The study, published in the journal Nature(link is external), was led by the Global Lipids Genetics Consortium. The authors included researchers at the National Human Genome Research Institute.