On Jun. 7, 2021, MediciNova announced it had initiated a sheep study to investigate MN-166 (ibudilast) in an ovine model of chlorine-induced acute lung injury. Following treatment of the sheep with MN-166 (ibudilast) or control, the study evaluated pulmonary function, lung injury and edema formation, cardiopulmonary hemodynamics, and systemic vascular permeability.