On Jul. 13, 2022, Moderna announced it has now demonstrated significantly higher antibody titers against all tested variants, including Omicron BA.1 and BA.4/5 subvariant, ancestral virus, Alpha, Beta, Delta, and Gamma.

The company shared clinical data showing that 1 month after administration in participants who were previously vaccinated and boosted, a 50-µg booster does of mRNA-1273.214 elicited significantly higher neutralizing antibody responses against the Omicron subvariants BA.4 and BA.5 compared to the currently authorized booster, mRNA-1273.

Bivalent mRNA-1273.214 resulted in significantly higher neutralizing titers against Ba.4/5 compared to the currently authorized booster for participants without prior infection, with a geometric mean ratio of 1.69 (95% CI: 1.51-1.90). BA.4/5 neutralizing titers were 776 for mRNA 1273.214 (95% CI: 719, 838) compared with 458 for the currently authorized booster (95% CI: 421, 499) at 1 month after booster.

The BA.4/5 geometric mean fold rise (GMFR) from pre-booster levels was 6.3-fold (95% CI: 5.7, 6.9) for participants who received mRNA-1273.214 and 3.5-fold (95% CI: 3.2, 3.9) for participants who received mRNA-1273.

Consistent results were demonstrated across subgroups. These findings showed that the dose of mRNA-1273.214 elicited significantly higher neutralizing antibody response against the Omicron subvariants BA.4/5 compared to the current booster regardless of prior infection status or age, according to Moderna.