On Jun. 26, 2023, the Centers for Disease Control and Prevention (CDC) announced they were collaborating with U.S. state health departments in Florida and Texas with ongoing investigations of locally acquired mosquito-transmitted Plasmodium vivax malaria cases. There was no evidence to suggest the cases in the two states (Florida and Texas) are related.

Locally acquired mosquito-borne malaria has not occurred in the U.S. since 2003 when eight cases of locally acquired P. vivax malaria were identified in Palm Beach County, Florida.