On Mar. 20, 2020, a study was published in JAMA that expands the understanding of influenza-associated complications. Influenza virus infection generally causes self-limited respiratory symptoms. The Centers for Disease Control and Prevention (CDC) estimated that 140,ﾠ000 to 810ﾠ,000 hospitalizations and 12ﾠ,000 to 61,ﾠ000 deaths among adult patients are attributable to influenza in the U.S. annually depending on the season.

In this cross-sectional analysis of more than 80,ﾠ000 adults hospitalized with laboratory-confirmed influenza between 2010 and 2018 in the U.S., 95% of patients had a respiratory diagnosis, and 46% had a nonrespiratory diagnosis, including 5% with exclusively nonrespiratory diagnoses.