On Nov. 9, 2015, the Human Dark Proteome Initiative was launched. The initiative aimed to accelerate research into biologyﾒs ﾓinvisible massﾔ to provide novel insights into cell function and a new frontier in drug discovery.

The term ﾓdark proteomeﾔ describes the large portion of the proteomeﾗthe complete collection of proteins in an organismﾗthat do not adopt defined 3D structures. These proteins make up about one third of the human proteome and control many aspects of cellular behavior.