Stanford Medicine researchers discovered the ‘homing receptor’
In 1989, Stanford Medicine researchers discovered the ‘homing receptor,’ which guides white blood cells into the peripheral lymph nodes. In a human, lymphocyte binding to high endothelial venules (HEVs) involves specific 85-95 kd cell surface glycoprotein(s) recognized by the monoclonal antibodies Hermes-1 and Hermes-3. These putative “homing receptor” molecule(s) were believed to play an important role in the normal regulation of lymphocyte circulation.
The results indicated that homing receptor antigen expression, although perhaps necessary for wide-spread blood-borne lymphoma dissemination to lymphoid sites, is not in and of itself sufficient to predict such behavior in this subtype of lymphoid malignancy.
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Source: National Library of Medicine
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