Typhoid vaccines were first developed
In 1896, Almroth Edward Wright, Richard Pfeiffer and Wilhelm Kolle developed the first typhoid vaccine. It was a heat-killed, phenol-preserved, and acetone-killed lyophilized injectable whole-cell S. Typhi vaccine that was used in England and Germany.
The efficacy of this vaccine was assessed in a trial in 1960 in Yugoslavia, Russia, Poland, and Guyana. Although licensed in few countries, this vaccine is no longer used due to its side effects.
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Source: U.S. National Library of Medicine
Credit: Photo: Transmission electron microscopic image of salmonella bacteria (pink), a common cause of foodborne disease, invade a human epithelial cell. Courtesy: National Institute of Allergy and Infectious Diseases.
