In 1892, the original building of the Wistar Institute was constructed, and today still a part of the Instituteﾒs research facility, was designed by Philadelphia architects George W. and William G. Hewitt, and sits at the corner of 36th and Spruce streets. The Institute is listed in the National Register of Historic Places as part of the historic university area, and is also recognized by a historic marker from the Pennsylvania Historical and Museum Commission.